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IKKγ NBD Inhibitory Peptide

CAS No. 372146-18-4

IKKγ NBD Inhibitory Peptide( —— )

Catalog No. M30314 CAS No. 372146-18-4

A cell-permeable synthetic peptide NEMO-binding domain peptide (NBD peptide) corresponding to the NEMO amino-terminal alpha-helical region is shown to block TNF-alpha-induced NF-kB activation. The interaction of IKγNEMO with the IKK complex is vital for the activation of the IKK complex and the subsequent activation of NF-kB.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    IKKγ NBD Inhibitory Peptide
  • Note
    Research use only, not for human use.
  • Brief Description
    A cell-permeable synthetic peptide NEMO-binding domain peptide (NBD peptide) corresponding to the NEMO amino-terminal alpha-helical region is shown to block TNF-alpha-induced NF-kB activation. The interaction of IKγNEMO with the IKK complex is vital for the activation of the IKK complex and the subsequent activation of NF-kB.
  • Description
    A cell-permeable synthetic peptide NEMO-binding domain peptide (NBD peptide) corresponding to the NEMO amino-terminal alpha-helical region is shown to block TNF-alpha-induced NF-kB activation. The interaction of IKγNEMO with the IKK complex is vital for the activation of the IKK complex and the subsequent activation of NF-kB.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Adult male Sprague-Dawley rats (255 g) with middle cerebral artery occlusion (MCAO)Dosage:40 μg/4 μL Administration:Intracerebroventricular injection; 2 h before MCAO induction Result:Significantly reduced striatal IL-1b level in IKK-NBD peptide treated rats.Also resulted in reduced staining of microglial OX-42 and protection of BBB from ischemic insult.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    372146-18-4
  • Formula Weight
    3693.3
  • Molecular Formula
    C170H259N49O42S1
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    Sequence:{Asp}{Arg}{Gln}{Ile}{Lys}{Ile}{Trp}{Phe}{Gln}{Asn}{Arg}{Arg}{Met}{Lys}{Trp}{Lys}{Lys}{Thr}{Ala}{Leu}{Asp}{Trp}{Ser}{Trp}{Leu}{Gln}{Thr}{Glu}

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

Zhao J, et al. Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation. PLoS Biol. 2018 Jun 11;16(6):e2004663.
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