IKKγ NBD Inhibitory Peptide( —— )

Catalog No. M30314 CAS No. 372146-18-4

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Product Name

IKKγ NBD Inhibitory Peptide
Note

Research use only, not for human use.
Brief Description

A cell-permeable synthetic peptide NEMO-binding domain peptide (NBD peptide) corresponding to the NEMO amino-terminal alpha-helical region is shown to block TNF-alpha-induced NF-kB activation. The interaction of IKγNEMO with the IKK complex is vital for the activation of the IKK complex and the subsequent activation of NF-kB.
Description

A cell-permeable synthetic peptide NEMO-binding domain peptide (NBD peptide) corresponding to the NEMO amino-terminal alpha-helical region is shown to block TNF-alpha-induced NF-kB activation. The interaction of IKγNEMO with the IKK complex is vital for the activation of the IKK complex and the subsequent activation of NF-kB.
In Vitro

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In Vivo

Animal Model:Adult male Sprague-Dawley rats (255 g) with middle cerebral artery occlusion (MCAO)Dosage:40 μg/4 μL Administration:Intracerebroventricular injection; 2 h before MCAO induction Result:Significantly reduced striatal IL-1b level in IKK-NBD peptide treated rats.Also resulted in reduced staining of microglial OX-42 and protection of BBB from ischemic insult.
Synonyms

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Pathway

Others
Target

Other Targets
Recptor

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Research Area

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Indication

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CAS Number

372146-18-4
Formula Weight

3693.3
Molecular Formula

C170H259N49O42S1
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

Sequence:{Asp}{Arg}{Gln}{Ile}{Lys}{Ile}{Trp}{Phe}{Gln}{Asn}{Arg}{Arg}{Met}{Lys}{Trp}{Lys}{Lys}{Thr}{Ala}{Leu}{Asp}{Trp}{Ser}{Trp}{Leu}{Gln}{Thr}{Glu}